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Age-Related Macular Degeneration Disease

Overview of Age-Related Macular Degeneration (AMD)

What is Age-Related Macular Degeneration (also known as AMD)?

  • Genetically determined weakening of the cells in the central retina called macula
  • Deterioration of cones, rods and retinal pigment epithelial cells
  • Cellular malfunction and death

Who is Affected?

  • 14% of people age 55-64
  • 20% of people age 65-74
  • 40% of people age over 75

    Age-Related Macular Degeneration is a true public health issue, 14 million had Macular Degeneration in 1996.
    Learn more about who is at a higher risk.

What Does AMD Do?

  • Early stages are asymptomatic or show diminished adjustment from light to dark
  • As the condition progresses blurring and reading difficulties begin
  • Generally the progression is very slow
  • In late phases all central vision is lost

AREDS study on macular degeneration

National Institute of Health:

Study Results

Press Release


Eye Institute's FAQs

normal vision without macular degeneration
Description: Normal vision.

Credit: National Eye Institute, National Institutes of Health
vision loss from macular degeneration
Description: A scene as it might be viewed by a person with Age-Related Macular Degeneration.

Credit: National Eye Institute, National Institutes of Health
   

The Cell Story

  • RPE cells have a very high rate of metabolism and oxidation
  • Rods and cones create metabolic debris which cells have to remove or die from choking
  • Deposits of debris form Drusen is an early sign of Age-Related Macular Degeneration

Molecular Level

  • High PUFA (polyunsaturated fatty acids) content in the retinal cells
  • PUFA oxidize under influence of light and oxygen and release free radicals
  • Ultraviolet and blue wave lengths promote oxidation

What are the Retinal Natural Antioxidants?

  • Vitamins E and C and Glutathione
  • Enzymes superoxide Desmutase and Glutathione Peroxidase
  • Carotenoids Zeaxanthin and Luteine
  • Beta Carotene is not normally present in the eye

What Can Be Done to Control Age-Related Macular Degeneration Damage?

Types of Macular Degeneration

  • Drusen and early pigment
  • Dry Macular Degeneration
  • Wet Macular Degeneration
  • Hemorrhagic form
  • Disciform or scarred form
stages of macular degeneration

Early Dry AMD

  • For diagnosis need complete eye examination
  • 90% of all Macular Degeneration cases remains dry

Wet or Hemorrhagic AMD

  • 10 to 15% of patients with Macular Degeneration will develop Wet Stage
  • Most will progress to Hemorrhagic Stage and then later to Cicatritial Stage

    These statistics are improving as more people are getting educated and applying what they learn.

What Can Be Done?

  • Make early diagnosis and work on prevention
  • Do NOT accept the idea that nothing can be done

Positive Breaking News!!

  • On October 12,2001 National Eye Institute (NEI) & NIH released the long awaited AREDS study
    • 5000 patients followed for 5 years
    • Proved that antioxidants & minerals reduced the risk of AMD by 25%!

Antioxidants & Minerals are Needed to Reduce the Risk of AMD

  • Vitamins
  • Enzymes
  • Trace metals
  • Carotenoids
  • Other pigments
  • Bioflavonoids
  • Glutathione boosters

Role of Vitamins

  • Beta Carotene is a water soluble proVitamin "A", antioxidant
  • Vitamin "C" is an antioxidant and protects Vitamin E from being oxidized
  • Vitamin "E" is a fat soluble antioxidant that combines with Selenium and in turn protects Vitamin "A" from oxidation

Role of Enzymes

  • Superoxide Dismutase antioxidant which destroys free radicals
  • Requires Zinc for synthesis
  • Glutathione is a naturally occurring antioxidant
  • Needs selenium for synthesis
  • Glutathione Peroxidase detoxifies Hydrogen Peroxide

Role of Trace Metals

  • Zinc, when low may impair dark adaptation
  • Too much Zinc may interfere with Copper absorption
  • Selenium is needed for synthesis of Glutathione
  • Chromium is an integral part of cell membranes

Role of Carotenoids

  • Lutein is a very important antioxidant in the macula
  • Zeaxanthin, another macular pigment, absorbs blue light and modifies cell membrane stability

Role of Other Pigments

  • Bilberry is an anthocyanin which retards the breakdown of Vitamin "C"
    It works on collagen in the capillaries and it improves night vision
  • Cranberry and Grape Seed also are also anthocyanins

Role of Bioflavonoids

  • Taurine fills photoreceptors and is an antioxidant
  • Quercitin prevents buildup of lipofuscin that makes up Drusen
  • Ginkgo biloba is a pro antho-cyanidine

Clinical Experience from Ophthalmologists who Developed NutriVision™

Results from AMD Patients Placed on the Antioxidant Mineral Supplement

  • Dry to Wet AMD conversion reduced 5-fold
  • Reduction in AMD progression matches AREDS study

New Treatments

  • Photodynamic Therapy (PDT) uses dyes such as Verteporfin
    • Dye goes to new vessels which leak in the macula
    • Dye is sensitive to a specific red laser in a very small dose energy
    • The reaction of laser and dye obliterates the leaky vessels

    At this time, applies to around 5% of Wet Macular Degeneration

  • Radiation with proton beam
  • Thermal Laser Photo-Coagulation
    Applies to a greater number of Wet cases

Ophthalmologist Recommendations

  • Review your risk factors and change your life style
  • With AMD diagnosed or if you are related to someone diagnosed, begin a committed antioxidant program
  • Protect your eyes from Ultra Violet and Blue wave lengths

Why NutriVision™?

  • Researched and formulated by Ophthalmologists
  • Ingredients regularly kept current with proven findings in eye nutrition related to AMD
  • Only two taken per day, one in the morning and one in the evening
  • Reasonably priced

Learn more about how NutriVision™ can help.

Why Does NutriVision™ Include Chinese Herbs?

  • Chinese have used healing herbs for 3000-4000 years
  • Gochee Berry lowers cholesterol and reduces capillary fragility
  • Ginseng improves blood flow to the brain, improves memory, concentration, and decreases fatigue
  • Ginkgo improves brain blood flow and is a mild blood thinner of 24 hours duration

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